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New Study: Cannabis Can Slow, Cure Alzheimers Disease

Category: Medical Marijuana | Posted on Wed, July, 17th 2013 by THCFinder
curing-ailments
 
A new study conducted by researchers at the Roskamp Institute in Florida, and published in the journal Molecular and Cellular Neuroscience, has found that cannabis can slow the effects of Alzheimer’s Disease, and may in fact be able to halt it entirely.
 
According to Corbin Bachmeier, Ph.D – who’s the lead researcher of the study – Alzheimer’s Disease is “the result of impaired Aβ [Amyloid-β protein] clearance from the brain”. According to this study, cannabis can solve this problem, making it a potential treatment.
 
Here’s the study’s abstract:
 
Emerging evidence suggests beta-amyloid (Aβ) deposition in the Alzheimer’s disease (AD) brain is the result of impaired clearance, due in part to diminished Aβ transport across the blood-brain barrier (BBB). Recently, modulation of the cannabinoid system was shown to reduce Aβ brain levels and improve cognitive behavior in AD animal models. The purpose of the current studies was to investigate the role of the cannabinoid system in the clearance of Aβ across the BBB. Using in vitro and in vivomodels of BBB clearance, Aβ transit across the BBB was examined in the presence of cannabinoid receptor agonists and inhibitors. In addition, expression levels of the Aβ transport protein, lipoprotein receptor-related protein1 (LRP1), were determined in the brain and plasma of mice following cannabinoid treatment. Cannabinoid receptor agonism or inhibition of endocannabinoid-degrading enzymes significantly enhanced Aβ clearance across the BBB (2-fold). Moreover, cannabinoid receptor inhibition negated the stimulatory influence of cannabinoid treatment on Aβ BBB clearance. Additionally, LRP1 levels in the brain and plasma were elevated following cannabinoid treatment (1.5-fold), providing rationale for the observed increase in Aβ transit from the brain to the periphery. The current studies demonstrate, for the first time, a role for the cannabinoid system in the transit of Aβ across the BBB. These findings provide insight into the mechanism by which cannabinoid treatment reduces Aβ burden in the AD brain and offer additional evidence on the utility of this pathway as a treatment for AD.
 
This research validates past studies (including some presented earlier this year, as well as a 2006 study), though is the first to actually explain why cannabis can be beneficial to the disease.
 

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U2 OG

Category: Nugs | Posted on Tue, July, 16th 2013 by THCFinder

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Pa. governor hopeful wants legal marijuana

Category: Legalization | Posted on Tue, July, 16th 2013 by THCFinder
legalize-mmj-now-pa
 
A Democratic challenger to Governor Tom Corbett says Pennsylvania should reform its marijuana laws.
 
John Hanger said medicinal marijuana should be permitted, and penalties for possessing small amounts of marijuana should be reduced to a summary offense similar to a traffic ticket by 2015.
 
He said Pennsylvania should regulate and tax marijuana use by 2017.
 
Hanger announced his plan during a news conference at the state Capitol.
 
He said Pennsylvania is spending $325 million a year prosecuting non-violent people for possessing marijuana, when regulating and taxing marijuana could bring the state at least $24 million a year.
 
Hanger was secretary of the state Department of Environmental Protection for three years under Governor Ed Rendell. He is among a field of Democrats seeking the gubernatorial nomination next year.
 
The other candidates are U.S. Rep. Allyson Schwartz, former Revenue secretary Tom Wolf, former DEP secretary Kathleen McGinty, Lebanon County commissioner Jo Ellen Litz, and Mechanicsburg minister Max Myers. State Treasurer Rob McCord is also exploring a bid.
 

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What are you Medicating on?

Category: Tokers | Posted on Tue, July, 16th 2013 by THCFinder

stoners-sexy


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Legalizing Marijuana May Help Save the US Economy

Category: Legalization | Posted on Tue, July, 16th 2013 by THCFinder
legalize-mj-boost-the-economy
 
For his book "Too High to Fail," author Doug Fine took off to Mendocino, California, where growing marijuana is big business. A tolerant county sheriff sees pot as a source of much-needed revenue for his department and local government, even as the Obama administration sporadically swoops down on medical marijuana dispensaries.
 
Entering the gray zone of the green revolution in northern California, Fine documents an entrepreneurial spirit that represents a key feature of the stereotype of the American dream: risk and innovation in pursuit of monetary gain. Fine, however, repeatedly reminds us that these are investors with a mission: the full legalization of marijuana.
 
Given the passage of the recent statewide initiatives legalizing pot in Colorado and Washington State, Fine's exploration of the Mendocino model provides insight into what is very possibly in store for many states in America.
 
As Bill Maher noted of Fine's book, “Fine has written a well-researched book that uses the clever tactic of making the moral case for ending marijuana prohibition by burying it inside the economic case.”
 

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Beautiful Purple Zombie Weed

Category: Nugs | Posted on Tue, July, 16th 2013 by THCFinder

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