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Spark one for the morning
Category: Tokers | Posted on Thu, March, 8th 2012 by THCFinder
Medicate in the morning.
Around the Weed Wide Web
Category: Fun | Posted on Wed, March, 7th 2012 by THCFinder
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Obama was baked
Category: Fun | Posted on Wed, March, 7th 2012 by THCFinder
Took a few too many hits before going live.
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'Marijuana' Diet Pill May Be Possible, Endocannabinoid Study Suggests
Category: News | Posted on Wed, March, 7th 2012 by THCFinder
Is the skinny pill right around the cornor? Would this be a game changer for society if our entire planet was filled with modelesque looking people without anyone looking larger than life? Would this change the game for models, actors, and other industries that hire people based on looks? If everyone was naturally skinny, would society stop working out, would gyms cease to exist becuase only the few would continue to work hard for muscle mass? This would be an interesting leap in the medical world if we could pop a pill and stop gaining wait!
A dreamy diet pill that someday allows people to eat as much as they want without gaining weight seems possible, based on new research into certain brain chemicals that influence how quickly we burn fat.
Scientists used lab mice to turn down brain levels of endocannabinoids, chemicals produced by our bodies that are similar in molecular structure to the active ingredients in marijuana.
Previous research has found that endocannabinoids play an important role in regulating energy metabolism. In the new study, blocking the activity of endocannabinoids in the brain enabled mice to stay skinny without exercise or dieting. The researchers explained that the mice were in a "hypermetabolic state," in which their bodies were using up energy (that is, calories) at a much higher rate than normal.
"We discovered that these mice were resistant to obesity because they burned fat calories much more efficiently than normal mice do," study researcher Daniele Piomelli, a professor at the University of California, Irvine, said in a statement. "We had known that endocannabinoids play a critical role in cell energy regulation, but this is the first time we found a target where this occurs."
This target is a compound called 2-AG, found in high levels in mammalian brains, and researchers think it plays a role in the brain circuits controlling how the body uses energy, which we get from food.
A previous study by Piomelli found these compounds make us crave fat. To see if lowering the levels of these compounds had the opposite effect, Piomelli engineered the brain cells of mice to express only low levels of this compound, then compared the animals' behavior and health with that of normal mice.
The modified mice ate more and moved less than their normal counterparts, but stayed skinny even on a high-fat diet. Not only did they look healthy, they had normal blood pressure, and no increased risk of heart disease and diabetes that usually come with a high-fat diet.
The researchers determined that the modified mice's brown fat was overactive — it was being turned into heat much quicker than in the normal mice. Brown fat is a type of fat that keeps mammals warm, and this heat creation burns off excess energy.
Jumping from lab studies in mice to actual health benefits for humans is still a ways away, though, since it is difficult to make a drug that acts only in one brain area.
"To produce the desired effects, we would need to create a drug that blocks 2-AG production in the brain, something we're not yet able to do," Piomelli said. "So don't cancel that gym membership just yet."
The study was published today (March 6) in the journal Cell Metabolism.
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San Francisco Might Have More Medical Marijuana Users Than Black People
Category: Medical Marijuana | Posted on Wed, March, 7th 2012 by THCFinder
A very odd statistic but interesting to see the stats on the growth of medical marijuana patients.
The medical marijuana movement and hyperbole often go hand-in-hand. It wasn't more than a few years ago that the office of George W. Bush's drug czar spread the rumor that there were more pot clubs in San Francisco than Starbucks coffee shops, a drum they banged loudly and proudly (and one that, upon the slightest inspection, turned out to be mostly made up).
Some statistics you can prove, some you need to estimate. Numbers from the US Census -- which say there are 48,000 African-Americans in San Francisco in 2010 -- are a mixture of both. The number of medical marijuana patients in San Francisco is almost entirely an estimation -- there's no "master list" of people recommended marijuana by a physician sitting around in a cop's drawer -- but is guessed to be about 30,000 on the low end, and over 50,000 on the high end (it was about 45,000 a few years ago, according to medical marijuana advocacy group Americans for Safe Access).
So: More medical marijuana patients than black people in San Francisco? Quite possibly. And, if not now -- as the black population dropped 20 percent from 2000 to 2010, according to Census figures -- almost definitely soon.
The reasons for African-American out-migration are too numerous and heavy for us to properly delve into here, but the trend has been going for some time, according to reports issued in 2008 and 1993.
Meanwhile, the paper trail created when a person becomes a medical marijuana patients is very short: The clinic -- be it legitimate doctor or plywood booth on Venice Beach -- keeps a copy of the recommendation, and the patient has a copy. One can go a step further and request a state-issued ID card through the local county health department, but it is voluntary, and no entity at the state or county level has a registry or list of all patients.
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