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Medical Marijuana

New Study Finds Marijuana Could Help Treat Alzheimers Disease

Category: Medical Marijuana | Posted on Mon, September, 9th 2013 by THCFinder
cannabis-fights-Alzheimers-diseaseA new study published by the journal Neurobiology of Aging has found that marijuana might actually help treat Alzheimer’s disease.
 
Based on a series of experiments with mice, researchers believe that they have evidence which shows that Alzheimer’s disease is worsened by a deficiency in the body’s cannabinoid receptors, indicating that the disease could be treated with cannabis.
 
According to the study’s abstract:
 
Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits. Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition. Here, we studied the impact of cannabinoid receptor type 1 (CB1) deficiency on the development of AD pathology by breeding amyloid precursor protein (APP) Swedish mutant mice (APP23), an AD animal model, with CB1-deficient mice. In addition to the lower body weight of APP23/CB1−/− mice, most of these mice died at an age before typical AD-associated changes become apparent.
 
The surviving mice showed a reduced amount of APP and its fragments suggesting a regulatory influence of CB1 on APP processing, which was confirmed by modulating CB1 expression in vitro. Reduced APP levels were accompanied by a reduced plaque load and less inflammation in APP23/CB1−/− mice. Nevertheless, compared to APP23 mice with an intact CB1, APP23/CB1−/− mice showed impaired learning and memory deficits. These data argue against a direct correlation of amyloid plaque load with cognitive abilities in this AD mouse model lacking CB1
 

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Alaskans may get chance to 'just say yes' on marijuana ballot measure

Category: Medical Marijuana | Posted on Sun, September, 8th 2013 by THCFinder
For more than 30 years, Alaska's libertarian streak made it the only state in which it was legal, under some circumstances, to smoke marijuana just for the fun of it.
 
alaskans-mmj-voteThen along came voters in Colorado and Washington state. Last year, both states passed initiatives legalizing pot and setting up rules for production, sales and taxation.
 
Now backers of a similar initiative here say they are close to giving Alaskans the same opportunity to just say yes. They're nearly halfway to reaching their goal of getting 45,000 signatures by Dec. 1, about 15,000 more than the number needed to put the measure on the 2014 primary election ballot, according to Timothy Hinterberger, the measure's main sponsor.
 
The initiative would add a new seven-page chapter to Alaska's statute books, making it legal for adults at the age at which they may buy beer to also possess up to an ounce of pot anywhere, except where a property owner banned it. It would set up a state regulatory body to oversee cannabis farms, dealers and advertising, and ensure that products don't end up with juveniles or on the black market. The initiative would impose a $50-an-ounce excise tax that would be collected between the greenhouse and the store or factory.
 
Employers would still be able to ban smoking or possession at work and prevent employees from being high on the job. Driving under the influence would still be illegal, and local governments could outlaw pot growing and sales -- but not possession -- by local option. Police officers would have to stop their current practice of seizing small amounts of marijuana when they encounter it. The measure would authorize retail pot shops but not dope dens, parlors or bars.
 
Read more: http://www.adn.com

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Medical marijuana used for childs epilepsy

Category: Medical Marijuana | Posted on Sun, September, 8th 2013 by THCFinder
3yearold-given-medical-cannabisMARTINSBURG - Even though she's far from home, there's no mistaking the determination in Tara White's voice.
 
She talks via cellphone about how the use of medical marijuana could help her chronically ill, nearly 3-year-old son Brandon, who suffers from a rare type of epilepsy, why it means so much to his quality of life, and how much she's willing to do to help him feel better.
 
Local residents, the mother-son duo have been in Denver, Colo., for a month and have just achieved their medical marijuana goal, White said, adding that the final doctor's recommendation was given Wednesday.
 
Since being approved, the youngster - who will celebrate his third birthday Sept. 18 - received a brownish liquid that will hopefully meet his medical needs. It still contains the compound in marijuana - cannabiodiol (CBD) - that has positive medical effects, but lower levels of tetrahydrocannabinol (TCH) which is associated with the being "stoned," she said, adding that there's also some evidence that CBD can help counter the effects of TCH.
 
Although excited, White was also nervous about getting her son started on the medicine. She said the dosage will gradually increase as doctors evaluate his reaction - and, hopefully, progress.
 

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Activation Of Cannabinoid Receptors May Treat Alzheimers Disease

Category: Medical Marijuana | Posted on Sat, September, 7th 2013 by THCFinder
cannabis-helps-treat-alzheimersA new study published by the journal Neurobiology of Aging has found promising evidence to suggest that Alzheimer’s disease is significantly worsened by a deficiency in the body’s cannabinoid receptors, indicating that the disease could be treated with cannabis, which naturally activates these receptors.
 
For the study, researchers implanted mice with Alzheimer’s disease, and examined a control group compared to a group which was deficient in cannabinoid receptors. Researchers found that the mice which were deficient in a particular cannabinoid receptor “showed impaired learning and memory deficits” compared to the control group.
 
According to the study’s abstract, “The surviving mice showed a reduced amount of APP and its fragments suggesting a regulatory influence of CB1 on APP processing, which was confirmed by modulating CB1 expression in vitro”.
 
Researchers conclude that these “findings indicate that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target.”
 
These findings help to confirm a study published recently in the journal Molecular and Cellular Neuroscience, which found that cannabis can slow, and potentially even cure Alzheimer’s disease.
 

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New Study Finds Cannabis May Provide Treatment For Skin Diseases

Category: Medical Marijuana | Posted on Fri, September, 6th 2013 by THCFinder
cannabis-good-for-skin-disesesA new study, recently published online in the British Journal of Pharmacology, details how cannabinoids can play a role in the treatment of skin diseases.
 
Researchers looked at the impact of phytocannabinoids (plant-derived cannabinoids, rather than synthetic counterparts) on epigenetic regulation of skin differentiation genes.
 
The study found that both cannabidiol (CBD) and cannabigerol (CBG), “significantly reduced the expression of all genes tested via increased DNA methylation for keratin 10 gene”.
 
The CBD was found to reduce keratin 10 mRNA through stimulating type-1 cannabinoid (CB1) receptors, while the CBG was found to act through a secondary method that did not engage the CB1 or CB2 receptors of keratinocytes (HaCaT cells). It was also revealed that cannabidiol increased global DNA methylation levels.
 
The study concludes that cannabis could act as a primary treatment for epidermal ailments:
 
“These findings identify the phytocannabinoids cannabidiol and cannabigerol as transcriptional repressors that can control cell proliferation and differentiation, suggesting (especially for cannabidiol) a possible exploitation as lead compounds to be used in the development of novel therapeutics for skin diseases.”
 
This report was conducted by researchers at the University of Teramo, the Campus Bio-Medico University and the Santa Lucia Foundation, all located in Italy.
 

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Medical marijuana patients ask review panel to add post-traumatic stress disorder to Michigan law

Category: Medical Marijuana | Posted on Fri, September, 6th 2013 by THCFinder
trying-to-get-ptsd-added-to-mi-rulesLANSING, MI -- Lillith Gwener survived sexual and physical abuse as a child, but she couldn't make it through a PG-13 movie this week without shaking and sobbing.
 
Gwener, 46, has lived most of her life with post-traumatic stress disorder, and her symptoms can be triggered by a variety of stimuli. Wednesday night, a violent scene in "The Butler" set her off.
 
"You're always in fight or flight," she said. "You're always afraid. Like me going to see this movie last night. I'm sitting in a movie and all of a sudden I'm shaking, I'm hyperventilating and I'm going through a pure anxiety attack."
 
Gwener was one of roughly 20 patients, activists and entrepreneurs who testified Thursday afternoon at a public meeting of the Michigan Marihuana Review Panel, which is considering a citizen petition to add PTSD to the list of debilitating conditions suitable for treatment under the state's voter-approved law.
 
The Holland resident is certified to use medical marijuana for chronic pain, but she said the medication also has proved effective for her PTSD and insomnia.
 
"It gives me a moment between the event -- the trigger -- and what my brain does. It lets me take that minute and realize, 'Hey, this is just a movie. I'm not under attack.'"
 

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