Stoned Science: Interactions Between THC and CBD
Often when people smoke marijuana, all of the credit for the high is given to Δ9-tetrahydrocannabinol (THC), but this isn’t the whole story. Through previous discussions you might recall that cannabidiol (CBD), alone, does not get you high. While this is true, there are some important interactions to consider.
Does CBD affect the high that THC provides and how does it do so?
Our bodies are broken up into many systems (i.e. cardiovascular, respiratory, nervous, etc.), but one important system that doesn’t get much attention is the endocannabinoid system (ECS).
As you may have guessed, our ECS interacts with cannabinoids, such as THC and CBD. But it is more involved than you might imagine. The ECS is imperative to the body’s normal functioning—assisting in the regulation of pain and hunger to name a few.
New Study: Alcohol, Not Weed, Manipulates Brain Structure
We’ve been saying it for a long time, but now scientists are confirming: alcohol negatively manipulates the structure of the human brain and cannabis does no such thing.
The powers that be, especially within the deteriorating administration in the White House, continue to disseminate blatantly erroneous information about cannabis and ignore authoritative academic work, such as one most recent study.
Researchers from the University of Colorado, Boulder and the Oregon Health & Science University evaluated neuroimaging data among adults (18 to 55) and adolescents (14 to 18) and identified an association between alcohol use and negative changes in brain structure.
They identified no such association with cannabis.
The Biology of CBD
Previously in “The Chemistry of CBD,” we looked at the subtle changes in the structure of CBD versus that of THC and the potential differences in the resulting conformation of cannabinoid receptor-1 (CB1).
We discussed how minuscule changes can have large multiplicative effects down the biological stream. As with all things in this world, structure determines function. The structure of the molecule determines how it binds to the protein, the movement of the protein determines the resulting cellular action and the structure of neuronal networks determines our physical behaviors which can be measured through science!
A claim that was made in the preceding article posed that CBD has the opposite effects of THC.
There have been a few studies that look at the differences in behavior, as well as the effect of CBD on the behaviors elicited by THC. One study in particular took advantage of a technique known as functional magnetic resonance imaging (fMRI).
What are the Health Benefits of CBD?
Washington, D.C. To Give Minorities Preference for Getting into MMJ Industry
Members of the Washington D.C. Council advanced legislation to give local minority-owned companies a preference when applying for licenses to operate medical marijuana businesses.
While states generally don’t track the race and ethnicity of weed license applicants, it’s obvious to anyone who hasn’t been living under a rock for the past decade that most dispensaries and the vast majority of growing operations around the country are overwhelmingly dominated by white men.
This lack of minority representation is especially problematic given that African Americans were—and still are—disproportionately arrested and incarcerated during the War on Drugs, according to the American Civil Liberties Union (ACLU).
Marijuana use is roughly equal among blacks and whites, yet blacks are 3.73 times as likely to be arrested for possession, noteed the ACLU.
Balkan States Move Toward Medical Marijuana
Three of the Balkan states to emerge from the ashes of Yugoslavia a generation ago are now among the first countries in the ex-communist world to move toward embracing medical marijuana.
Australian firm MGC Pharmaceuticals just announced a deal to distribute its cannabis-derived products in Slovenia, Croatia and Bosnia. MGC is partnering with the Slovenian supplier Mikro+Polo to market its phytocannabinoid-derived Active Pharmaceutical Ingredients (APIs) in the three countries, according to Australia’s Business News.
Perth-based MGC was established three years ago by veterans of the Israeli medical marijuana industry. Late last year, it harvested its first test crop of cannabis in Slovenia and has established a facility in the country’s capital, Ljubljana, where it is isolating cannabidiol (CBD) for use in its products, including a CBD-infused skincare ointment.
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