'Marijuana' Diet Pill May Be Possible, Endocannabinoid Study Suggests

Category: News | Posted on Wed, March, 7th 2012 by THCFinder

Is the skinny pill right around the cornor? Would this be a game changer for society if our entire planet was filled with modelesque looking people without anyone looking larger than life? Would this change the game for models, actors, and other industries that hire people based on looks? If everyone was naturally skinny, would society stop working out, would gyms cease to exist becuase only the few would continue to work hard for muscle mass? This would be an interesting leap in the medical world if we could pop a pill and stop gaining wait!

A dreamy diet pill that someday allows people to eat as much as they want without gaining weight seems possible, based on new research into certain brain chemicals that influence how quickly we burn fat.
Scientists used lab mice to turn down brain levels of endocannabinoids, chemicals produced by our bodies that are similar in molecular structure to the active ingredients in marijuana.
Previous research has found that endocannabinoids play an important role in regulating energy metabolism. In the new study, blocking the activity of endocannabinoids in the brain enabled mice to stay skinny without exercise or dieting. The researchers explained that the mice were in a "hypermetabolic state," in which their bodies were using up energy (that is, calories) at a much higher rate than normal.
"We discovered that these mice were resistant to obesity because they burned fat calories much more efficiently than normal mice do," study researcher Daniele Piomelli, a professor at the University of California, Irvine, said in a statement. "We had known that endocannabinoids play a critical role in cell energy regulation, but this is the first time we found a target where this occurs."
This target is a compound called 2-AG, found in high levels in mammalian brains, and researchers think it plays a role in the brain circuits controlling how the body uses energy, which we get from food.
A previous study by Piomelli found these compounds make us crave fat. To see if lowering the levels of these compounds had the opposite effect, Piomelli engineered the brain cells of mice to express only low levels of this compound, then compared the animals' behavior and health with that of normal mice.
The modified mice ate more and moved less than their normal counterparts, but stayed skinny even on a high-fat diet. Not only did they look healthy, they had normal blood pressure, and no increased risk of heart disease and diabetes that usually come with a high-fat diet.
The researchers determined that the modified mice's brown fat was overactive — it was being turned into heat much quicker than in the normal mice. Brown fat is a type of fat that keeps mammals warm, and this heat creation burns off excess energy.
Jumping from lab studies in mice to actual health benefits for humans is still a ways away, though, since it is difficult to make a drug that acts only in one brain area.
"To produce the desired effects, we would need to create a drug that blocks 2-AG production in the brain, something we're not yet able to do," Piomelli said. "So don't cancel that gym membership just yet."
The study was published today (March 6) in the journal Cell Metabolism.


Senate Committee OKs Marijuana DUI Standard

Category: News | Posted on Tue, February, 28th 2012 by THCFinder
What if you had a test that showed that you had alcohol in your system from drinking 3 days ago and you could get a DUI!!! Well thats what could possibly happen with Denver giving the greenlight on their Marijuana DUI standard set for 5 nanograms which could potentially show a positive test result if you had smoked the day prior which would result in a DUI and a whole bunch of more trouble after that.
DENVER -- The hazy debate over driving while high is back before Colorado lawmakers, as a Senate committee voted Monday to endorse a proposal setting a scientific standard for determining whether drivers are impaired by marijuana.
The bill says drivers would be considered impaired if they test positive for 5 nanograms or more of THC, the psychoactive ingredient in marijuana, per milliliter of blood. There's disagreement over whether a blood THC test is a fair gauge of whether a driver is impaired, but a Senate panel voted 4-1 to forward the measure to the full chamber.
"The privilege of smoking marijuana should stop at the vehicle door," said the bill's sponsor, Republican Sen. Steve King, of Grand Junction.
Pot activists said they agree driving while high should remain illegal. But some vigorously object to blood testing as a measure of impairment. Because marijuana chemicals are stored in the body's fat, levels can build up over time in people who use pot often.
Scientists gave conflicting testimony Monday.
"Nobody in this audience wants to have drugged driving policies, (but) there is disagreement about per se limits in chronic users," said Dr. Paul Bregman, a Colorado physician who recommends marijuana.


Two NFL players charged with marijuana possession

Category: News | Posted on Tue, February, 28th 2012 by THCFinder

Apparently Atlanta police have nothing better to do with their time than to bust small time personal marijuana users in their own homes. You would think their time and tax payers hard earned money would be better spent going after serious criminals!

ATLANTA (AP) – Free agent linebacker Leroy Hill was arrested by police in Atlanta for possession of less than an ounce of marijuana.
According to a statement from Atlanta police on Monday, Hill was arrested early Saturday after officers were called to an Atlanta condominium following a complaint about a marijuana odor. Officers say they confirmed the smell, obtained a search warrant and found partially smoked blunts and marijuana residue inside.
The News Tribune of Tacoma, Wash., first reported Hill's arrest. Hill has spent his entire NFL career with the Seattle Seahawks.
In a statement Monday afternoon, the Seahawks said they were in the process of gathering information and would not be commenting at this time.
This isn't Hill's first run-in with off-field problems. He was arrested in January 2009 on a marijuana-possession charge in Georgia and was given 12 months of probation. He also was arrested on a domestic violence charge in a Seattle suburb in April 2010


Colorado revisits marijuana DUI standard

Category: News | Posted on Mon, February, 27th 2012 by THCFinder
DENVER (AP) -- Driving while high is illegal in Colorado, but state lawmakers are again entering a hazy debate over how to measure whether medical marijuana patients are impaired behind the wheel.
A bill up for a Senate hearing Monday would say that drivers would be considered impaired if they test positive for 5 nanograms or more of THC, the psychoactive ingredient in marijuana. Problem is that there's little agreement over whether the amount is a fair gauge of whether a driver is impaired.
Current Colorado law says drivers can't be impaired by drugs but does not set a THC limit. Pot activists say impairment and THC levels aren't directly related.
Marijuana activists called the 5-nanogram limit ``unfair'' because they say patients who use marijuana regularly see a gradual build-up of THC levels, even when sober.
The 5-nanogram limit ``is not supported by the science,'' argued Michael Elliott of the Medical Marijuana Industry Group, which opposes the bill.
Marijuana activists favor instead an education effort reminding patients they cannot legally drive high.
Last year, a similar DUI standard cleared the House but was defeated in the Senate amid concerns from both parties about the lack of agreement on an acceptable blood-level standard. A nonpartisan study committee that looked at the question during the summer and fall could not agree on what the standard should be.
The Republican sponsor of this year's bill says law enforcement needs a standard to measure impairment.
``It's time we had a clear standard,'' said Sen. Steve King, R-Grand Junction.


Why Synthetic Marijuana Is More Dangerous Than the Real Thing

Category: News | Posted on Fri, February, 24th 2012 by THCFinder
Synthetic marijuana, or "fake" pot, is nothing like the real thing. It's legal, and easily accessible to kids.
It's also a bigger threat to kids' health.
"Marijuana has been used for medicinal and recreational purposes for hundreds of years," said Dr. Jeff Lapoint, a senior toxicology fellow at New York University, Bellevue Hospital. "It's been abused, but no one really gets sick."
"Kids need to know that this substance is more dangerous," Lapoint said.
Popularly called K2, or Spice, synthetic marijuana is a chemical similar to cannabis that gives a marijuana-like high.
But there have been an increasing number of cases of people experiencing seizures, heart palpitations, fever, dehydration and some psychotic episodes after using the drug.
A more potent version of marijuana
Since 2004, K2 has been sold and packaged as incense or potpourri, in the guise of a mixture of herbs and spices. It sells for about $30 to $40 per 3-gram bag, comparable to the cost of marijuana.
Drugmakers can make hundreds of versions of the chemical compound, and it's easy to manufacture.
Although the Drug Enforcement Administration has taken steps to ban five chemicals sometimes found in K2, versions of the compound have multiplied, and increased in use over the past few years.
According to the National Institute on Drug Abuse, 11 percent of nearly 15,000 high school seniors surveyed reported using K2 in 2011.
That year, poison control centers reported handling nearly 7,000 calls about K2, nearly double the calls received in 2010.
One recent study suggests that K2 could increase the risk of psychosis, even among people with no history of a psychiatric disorder.
"K2 is a more potent substance than natural marijuana by its actions on the brain," said Dr. Ashwin Reddy, an author of that study and a psychiatrist at the Boston University School of Medicine. "It can cause an increased risk of paranoia, hearing voices, disorganized behavior and panic symptoms."
"Depending on the person, psychotic symptoms can last a few days to a few months," Reddy said.
Not intended for human use
K2 is sometimes reported as having originated in Europe, but was actually developed by John W. Huffman, a chemist at Clemson University in South Carolina.
Initially created as a medical treatment, the substance works on the brain the sameway as marijuana's active ingredient, tetrahydrocannabinol, or THC.
THC is the substance in marijuana that produces the "high" feeling of intoxication that pot smokers crave.
"This drug was never intended for people to use, just for use in a lab," Lapoint said.
But also disturbing is the unregulated amount of chemicals added in each package.
"You don't know how much of which chemical they put in each package so you don't know what you're getting and how your body will handle it," he said.
Pass it on: Synthetic pot is a more potent — and dangerous — form of marijuana.


Legal group goes to bat for eighth-grader suspended for using oregano in pot prank

Category: News | Posted on Wed, February, 22nd 2012 by THCFinder

Taking the punishment too far for a kids little prank.

An eighth-grader suspended after pranking a classmate with a bag of oregano following a lecture on the dangers of marijuana has a civil liberties group in his corner, but officials at his North Carolina school aren't backing down.
The boy was booted from his school for 55 days for the stunt at Cuthbertson Middle School in Waxhaw, N.C. School officials cite the district's policy manual, which says a student can get a 10-day suspension for "possessing illegal or counterfeit drugs and "misuse of chemical/material (organic or otherwise) that causes or is purported to cause a hallucinogenic/mind altering effect." A longer suspension can be imposed if officials determine a student's conduct "demonstrates a willful violation" of school policies.
"It was just a joke," the mother of the boy, who is not being identified because of his age, told in an exclusive interview. "He's embarrassed that it's turned into such a big issue. He's actually said he doesn't know why he did it. But he didn't have an illegal substance to begin with."
Luan Ingram, a spokeswoman for Union County Public Schools, confirmed to that the matter was handled according to its student discipline policy, but declined additional comment.
In a letter to Union County Public Schools officials, the Virginia-based Rutherford Institute called the suspension a "gross overreaction" to a childish prank and said it may be a violation of the boy's constitutional rights.
"We want the record cleaned up so this doesn't track him for the rest of his life," John Whitehead, president of the Rutherford Institute, told
Immediately after the incident last month, in which the boy passed the bag of seasoning to a pal a day after their health class discussed marijuana, the boy received a 10-day suspension. On Feb. 1, school officials notified the boy's family that he had been recommended for another 45 days of suspension. Their appeal of the additional term was denied this week, and the boy is attending a school for at-risk students until he is eligible to return to Cuthbertson on March 29.



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